DNASE2B

Across TCGA patient cohorts, DNASE2B protein abundance is significantly associated with the RNA expression of many other genes, with 3,045 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DNASE2B-associated genes across cancer lineages are FOSB, SEPSECS, and RN7SL600P. Each is linked with DNASE2B in more than 3 cancer types. Because this analysis shows association rather than direction, both DNASE2B-to-partner and partner-to-DNASE2B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DNASE2B versus FOSB in CCRCC, with a Pearson correlation of 0.64.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNASE2B→partner) and Y-score (partner→DNASE2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	FOSB →	+2.960	+0.725	<.001	.001	3	4
CCRCC	SEPSECS →	-0.944	-0.759	.002	.005	3	3
CCRCC	RN7SL600P →	+1.541	+0.683	.001	<.001	3	3
CCRCC	RNU1-1 →	+1.914	+0.750	<.001	.001	3	3
UCEC	PSMD10 →	-0.832	-0.672	<.001	.003	3	2
UCEC	ZNF16 →	-0.719	-0.598	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,045 associations by consensus.

DNASE2B vs FOSB — CCRCC

Explore this scatter interactively →