DNASE2B

Across TCGA patient cohorts, DNASE2B mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNASE2B-associated genes across cancer lineages are Annexin-1, EGFR_pY1068, and ATM. Each is linked with DNASE2B in more than 2 cancer types. Because this analysis shows association rather than direction, both DNASE2B-to-partner and partner-to-DNASE2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by DNASE2B-low versus DNASE2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNASE2B→partner) and Y-score (partner→DNASE2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.648	+2.827	.008	.035	3	3
UCEC	EGFR_pY1068 →	-0.230	-2.321	.049	.034	3	2
UCEC	ATM →	-0.724	-2.584	<.001	.011	3	2
UCEC	A-Raf_pS299 →	-0.163	-3.169	.003	.019	2	2
UCEC	Ku80 →	+0.270	+2.331	.014	.019	3	1
UCEC	Notch1 →	+0.184	+3.013	.005	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Annexin-1 by DNASE2B expression — UCEC

Explore this box plot interactively →