DNASE2B

Across TCGA cell cohorts, DNASE2B RNA expression is significantly associated with the go_rna of many other GO terms, with 1,391 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DNASE2B-associated GO terms across cancer lineages are Cellular respiration, Glucuronate metabolic process, and Aerobic respiration. Each is linked with DNASE2B in more than 5 cancer types. Because this analysis shows association rather than direction, both DNASE2B-to-partner and partner-to-DNASE2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular respiration grouped by DNASE2B-low versus DNASE2B-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DNASE2B→partner) and Y-score (partner→DNASE2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Cellular respiration →	+0.062	+0.762	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	Glucuronate metabolic process →	+0.086	+0.024	.001	.002	3	5
SKIN	Aerobic respiration →	+0.066	+0.762	<.001	.001	3	5
SKIN	Nucleoside triphosphate metabolic process →	+0.074	+0.821	<.001	.002	3	5
SKIN	Purine ribonucleoside triphosphate metabolic process →	+0.076	+0.937	<.001	<.001	3	5
SKIN	Vesicle localization →	+0.039	+0.722	<.001	.005	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,391 associations by consensus.

Cellular respiration by DNASE2B expression — SKIN

Explore this box plot interactively →