DNASE2B

Across TCGA cell cohorts, DNASE2B mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BONE shows the largest number of these associations.

The most reproducible DNASE2B-associated genes across cancer lineages are OR1L6, C2orf80, and WFDC8. Each is linked with DNASE2B in more than 1 cancer types. Because this analysis shows association rather than direction, both DNASE2B-to-partner and partner-to-DNASE2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L6 grouped by DNASE2B-low versus DNASE2B-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNASE2B→partner) and Y-score (partner→DNASE2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	OR1L6 →	+0.020	+5.169	<.001	.004	3	1
BONE	C2orf80 →	+0.126	+5.169	<.001	.004	3	1
LUNG_NSCLC_LUAD	WFDC8 →	+0.014	+3.604	<.001	.004	3	1
BLOOD_Lymphoma	ASB10 →	+0.177	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

OR1L6 by DNASE2B expression — BONE

Explore this box plot interactively →