DNASE2

Across TCGA patient cohorts, DNASE2 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,651 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DNASE2-associated proteins across cancer lineages are CC2D1A, COLGALT1, and DOCK10_S1257. Each is linked with DNASE2 in more than 5 cancer types. Because this analysis shows association rather than direction, both DNASE2-to-partner and partner-to-DNASE2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DNASE2 versus CC2D1A in OV, with a Pearson correlation of 0.48.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DNASE2→partner) and Y-score (partner→DNASE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CC2D1A →	+0.496	+0.726	<.001	<.001	3	6
OV	COLGALT1 →	+0.565	+0.705	<.001	<.001	3	5
LUAD	DOCK10_S1257 →	+0.610	+0.274	<.001	<.001	3	5
GBM	ITGAX →	+0.712	+0.514	<.001	<.001	3	5
UCEC	RAVER1 →	+0.226	+0.875	<.001	<.001	3	4
UCEC	NACC1 →	+0.292	+1.112	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,651 associations by consensus.

DNASE2 vs CC2D1A — OV

Explore this scatter interactively →