DNASE2

Across TCGA patient cohorts, DNASE2 mutation is significantly associated with the RNA expression of many other genes, with 441 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNASE2-associated genes across cancer lineages are MIR548W, RNU6-286P, and RNU6ATAC21P. Each is linked with DNASE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNASE2-to-partner and partner-to-DNASE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR548W grouped by DNASE2-low versus DNASE2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNASE2→partner) and Y-score (partner→DNASE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR548W →	+0.659	+6.191	<.001	.001	3	2
PRAD	RNU6-286P →	+0.323	+7.939	<.001	.008	3	1
PRAD	RNU6ATAC21P →	+0.278	+7.939	<.001	.008	3	1
UCEC	NUS1 →	+0.662	+3.343	.004	.005	3	1
UCEC	FAM126B →	+0.628	+3.210	<.001	.009	3	1
UCEC	STEAP2 →	+1.260	+3.332	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 441 associations by consensus.

MIR548W by DNASE2 expression — LUSC

Explore this box plot interactively →