DNASE2

Across TCGA patient cohorts, DNASE2 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNASE2-associated genes across cancer lineages are JNK2, P-Cadherin, and p70-S6K_pT389. Each is linked with DNASE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNASE2-to-partner and partner-to-DNASE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by DNASE2-low versus DNASE2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNASE2→partner) and Y-score (partner→DNASE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.254	+3.321	.014	.010	3	1
UCEC	P-Cadherin →	-0.201	-3.169	.007	.018	3	1
UCEC	p70-S6K_pT389 →	-0.248	-2.990	.012	.036	2	1
UCEC	Annexin-1 →	+0.752	+2.827	.006	.035	2	1
UCEC	cIAP →	+0.156	+2.196	.030	.034	2	1
UCEC	CD31 →	-0.166	-3.321	.031	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

JNK2 by DNASE2 expression — UCEC

Explore this box plot interactively →