DNASE2

Across TCGA cell cohorts, DNASE2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,612 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible DNASE2-associated GO terms across cancer lineages are ERAD pathway, Oligosaccharide catabolic process, and Response to endoplasmic reticulum stress. Each is linked with DNASE2 in more than 13 cancer types. Because this analysis shows association rather than direction, both DNASE2-to-partner and partner-to-DNASE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERAD pathway grouped by DNASE2-low versus DNASE2-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DNASE2→partner) and Y-score (partner→DNASE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ERAD pathway →	+0.094	+1.047	.001	.001	3	14
SOFT_TISSUE	Oligosaccharide catabolic process →	+0.177	+1.415	<.001	.001	3	13
BONE	Response to endoplasmic reticulum stress →	+0.090	+1.260	<.001	<.001	3	12
BONE	Response to unfolded protein →	+0.095	+1.251	.003	<.001	3	12
BONE	Homologous chromosome segregation →	-0.134	-0.909	.001	.001	3	12
BONE	Endoplasmic reticulum unfolded protein response →	+0.084	+0.889	.006	.006	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,612 associations by consensus.

ERAD pathway by DNASE2 expression — PANCREAS

Explore this box plot interactively →