DNASE1L3

Across TCGA pan-cancer cohorts, DNASE1L3 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of DNASE1L3’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where DNASE1L3 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types DNASE1L3 is over-expressed in tumor, although a few such as LUAD and CCRCC show the opposite, repressed pattern.

LUAD, CCRCC, and LSCC are the cancer types where DNASE1L3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DNASE1L3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	II,III,IV	−1.453	<.001	9	view →
CCRCC	Male	III,IV	−1.097	<.001	6	view →
LSCC	Male	All	−1.439	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

DNASE1L3–LUAD

Open the LUAD breakdown →