DNASE1L1

Across TCGA pan-cancer cohorts, DNASE1L1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DNASE1L1 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher DNASE1L1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DNASE1L1 expression acts as an unfavorable survival marker, although some lineages such as GBM and HNSC show a favorable association.

LSCC, GBM, and PDAC are the cancer types where DNASE1L1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.466	0.888	.006	31	view →
GBM	OS	Tertile	All	0.820	0.563	.007	6	view →
PDAC	OS	Tertile	All	0.308	0.589	.015	5	view →
CCRCC	DFS	Median	All	0.714	1.000	.045	5	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	5	view →
HNSC	DFS	Quartile	II,III,IV	1.000	0.911	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DNASE1L1–LSCC (DFS)

Open the LSCC breakdown →