DNASE1L1

Across TCGA cell cohorts, DNASE1L1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,116 significant associations in total. BONE shows the largest number of these associations.

The most reproducible DNASE1L1-associated GO terms across cancer lineages are Response to water, Regulation of G2/MI transition of meiotic cell cycle, and Viral gene expression. Each is linked with DNASE1L1 in more than 9 cancer types. Because this analysis shows association rather than direction, both DNASE1L1-to-partner and partner-to-DNASE1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to water grouped by DNASE1L1-low versus DNASE1L1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DNASE1L1→partner) and Y-score (partner→DNASE1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Response to water →	+0.153	+1.140	.005	.004	3	10
SOFT_TISSUE	Regulation of G2/MI transition of meiotic cell cycle →	-0.088	-0.961	.001	.004	3	10
BONE	Viral gene expression →	+0.111	+1.711	<.001	.002	3	10
LARGE_INTESTINE	Positive regulation of microtubule nucleation →	+0.114	+0.779	<.001	.001	3	10
OVARY	Maintenance of protein localization in organelle →	+0.098	+0.903	<.001	<.001	3	9
BONE	Proteinogenic amino acid metabolic process →	-0.074	-1.168	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,116 associations by consensus.

Response to water by DNASE1L1 expression — LUNG_NSCLC_LUSC

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