Across TCGA pan-cancer cohorts, DNASE1 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated DNASE1 data layer compared with 20 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher DNASE1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DNASE1 expression acts as an unfavorable survival marker.

LUAD and CCRCC are the cancer types where DNASE1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.359	0.925	.027	8	view →
CCRCC	OS	Median	II,III,IV	0.674	1.000	.017	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: DNASE1 tumor-vs-normal RNA expression · all DNASE1 data types