Across TCGA patient cohorts, DNASE1 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,894 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DNASE1-associated proteins across cancer lineages are USP7, CKAP4_S26, and GLYR1. Each is linked with DNASE1 in more than 5 cancer types. Because this analysis shows association rather than direction, both DNASE1-to-partner and partner-to-DNASE1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DNASE1→partner) and Y-score (partner→DNASE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	USP7 →	+0.232	+0.674	<.001	<.001	3	6
GBM	CKAP4_S26 →	-0.624	-0.612	<.001	<.001	3	6
GBM	GLYR1 →	+0.259	+0.375	<.001	<.001	3	6
LSCC	MEPCE →	+0.354	+0.399	<.001	.004	3	6
GBM	STAG2 →	+0.307	+0.355	<.001	<.001	3	5
GBM	CREBBP →	+0.235	+0.464	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,894 associations by consensus.

Exploration

DNASE1 survival (RNA) · tumor vs normal (RNA) · all DNASE1 data types