Across TCGA patient cohorts, DNASE1 mutation is significantly associated with the RNA expression of many other genes, with 1,837 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNASE1-associated genes across cancer lineages are MRPS11, C22orf46, and NF2. Each is linked with DNASE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNASE1-to-partner and partner-to-DNASE1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNASE1→partner) and Y-score (partner→DNASE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPS11 →	+0.430	+3.649	.002	.001	3	2
UCEC	C22orf46 →	+0.589	+3.592	<.001	.001	3	2
UCEC	NF2 →	+0.726	+3.483	<.001	.002	3	2
UCEC	NCR1 →	+0.372	+3.499	<.001	.002	3	2
UCEC	CDRT1 →	+0.368	+2.623	<.001	.008	3	2
UCEC	TMEM269 →	+0.238	+3.613	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,837 associations by consensus.

Exploration

DNASE1 survival (RNA) · tumor vs normal (RNA) · all DNASE1 data types