Across TCGA patient cohorts, DNASE1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNASE1-associated genes across cancer lineages are Cyclin-E2, IRS1, and Notch1. Each is linked with DNASE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNASE1-to-partner and partner-to-DNASE1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNASE1→partner) and Y-score (partner→DNASE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Cyclin-E2 →	+0.247	+2.832	.040	.034	3	2
UCEC	IRS1 →	+0.346	+2.321	<.001	.035	3	1
UCEC	Notch1 →	+0.143	+2.321	.043	.035	3	1
UCEC	p27_pT198 →	+0.110	+2.321	.041	.035	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.506	-3.000	.025	.036	3	1
UCEC	p62 Lck ligand →	+0.530	+2.321	.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

DNASE1 survival (RNA) · tumor vs normal (RNA) · all DNASE1 data types