DNASE1

RNA expression — cross-omics
Cross-omicsRNA → FUNCTION-RNACell-linePairwise association · TCGA cohorts

Across TCGA cell cohorts, DNASE1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,483 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DNASE1-associated GO terms across cancer lineages are Cilium-dependent cell motility, Cilium or flagellum-dependent cell motility, and Cilium movement involved in cell motility. Each is linked with DNASE1 in more than 17 cancer types. Because this analysis shows association rather than direction, both DNASE1-to-partner and partner-to-DNASE1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DNASE1→partner) and Y-score (partner→DNASE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner GO termX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UPPER_AERODIGESTIVE_TRACTCilium-dependent cell motility →-0.134-1.240<.001<.001318
UPPER_AERODIGESTIVE_TRACTCilium or flagellum-dependent cell motility →-0.134-1.240<.001<.001318
UPPER_AERODIGESTIVE_TRACTCilium movement involved in cell motility →-0.139-1.240<.001<.001317
STOMACHRegulation of myoblast fusion →+0.120+0.761.004.007316
UPPER_AERODIGESTIVE_TRACTSperm motility →-0.139-1.151<.001<.001316
UPPER_AERODIGESTIVE_TRACTFlagellated sperm motility →-0.139-1.151<.001<.001316
Each partner links to its Q-omics profile. Showing the 6 strongest of 5,483 associations by consensus.

Exploration