DNALI1

Across TCGA patient cohorts, DNALI1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNALI1-associated genes across cancer lineages are Rictor_pT1135, Notch1, and Shc_pY317. Each is linked with DNALI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNALI1-to-partner and partner-to-DNALI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rictor_pT1135 grouped by DNALI1-low versus DNALI1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNALI1→partner) and Y-score (partner→DNALI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rictor_pT1135 →	-0.179	-3.000	.002	.037	3	2
UCEC	Notch1 →	+0.289	+3.000	<.001	.037	3	1
UCEC	Shc_pY317 →	-0.176	-3.000	.045	.036	3	1
UCEC	PDCD4 →	-0.630	-3.000	.020	.037	2	1
UCEC	PKC-delta_pS664 →	-0.171	-3.000	.013	.037	1	2
UCEC	EGFR_pY1068 →	-0.324	-3.000	.025	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Rictor_pT1135 by DNALI1 expression — UCEC

Explore this box plot interactively →