DNAL4

Across TCGA pan-cancer cohorts, DNAL4 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated DNAL4 data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher DNAL4 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated DNAL4 expression acts as an unfavorable survival marker, although some lineages such as CESC show a favorable association.

CESC are the cancer types where DNAL4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	IV	1.000	0.170	.035	6	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

DNAL4–CESC (DFS)

Open the CESC breakdown →