DNAJC7

Across TCGA patient cohorts, DNAJC7 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAJC7-associated genes across cancer lineages are Lck, EGFR_pY1068, and ERK2. Each is linked with DNAJC7 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAJC7-to-partner and partner-to-DNAJC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lck grouped by DNAJC7-low versus DNAJC7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJC7→partner) and Y-score (partner→DNAJC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Lck →	+0.236	+2.222	.005	.011	3	2
UCEC	EGFR_pY1068 →	-0.214	-1.700	.044	.044	3	1
UCEC	ERK2 →	+0.189	+1.700	.020	.044	3	1
UCEC	ETS-1 →	+0.331	+3.321	.014	.009	3	1
UCEC	GATA3 →	+0.217	+2.235	.006	.006	3	1
UCEC	MIG-6 →	+0.117	+3.169	.005	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Lck by DNAJC7 expression — UCEC

Explore this box plot interactively →