DNAJC6

Across TCGA patient cohorts, DNAJC6 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAJC6-associated genes across cancer lineages are TFRC, ATM, and PKC-a_pS657. Each is linked with DNAJC6 in more than 2 cancer types. Because this analysis shows association rather than direction, both DNAJC6-to-partner and partner-to-DNAJC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by DNAJC6-low versus DNAJC6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJC6→partner) and Y-score (partner→DNAJC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.386	+2.000	.017	.029	3	3
UCEC	ATM →	-0.652	-2.794	<.001	<.001	3	3
BLCA	PKC-a_pS657 →	-0.458	-3.000	.007	.036	3	2
LUSC	FoxM1 →	+0.315	+3.009	.033	.019	2	3
SKCM	MYH11 →	-0.804	-2.584	.043	.011	3	2
UCEC	PDCD4 →	-0.526	-2.999	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

TFRC by DNAJC6 expression — UCEC

Explore this box plot interactively →