DNAJC6

Across TCGA cell cohorts, DNAJC6 mutation is significantly associated with the RNA expression of many other genes, with 443 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DNAJC6-associated genes across cancer lineages are PFN3, C1orf189, and FSHR. Each is linked with DNAJC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAJC6-to-partner and partner-to-DNAJC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PFN3 grouped by DNAJC6-low versus DNAJC6-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJC6→partner) and Y-score (partner→DNAJC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PFN3 →	+0.070	+4.450	<.001	.004	3	2
BLOOD_Lymphoma	C1orf189 →	+0.226	+4.052	<.001	<.001	3	2
LUNG_NSCLC_LUAD	FSHR →	+0.049	+3.362	<.001	.007	3	1
LUNG_NSCLC_LUAD	XAGE3 →	+0.126	+3.215	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR5J2 →	+0.066	+4.266	<.001	.004	3	1
BLOOD_Leukemia	LCE2A →	+0.053	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 443 associations by consensus.

PFN3 by DNAJC6 expression — OVARY

Explore this box plot interactively →