DNAJC5

Across TCGA patient cohorts, DNAJC5 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAJC5-associated genes across cancer lineages are Ku80, Rab11, and Cyclin-B1. Each is linked with DNAJC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAJC5-to-partner and partner-to-DNAJC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by DNAJC5-low versus DNAJC5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJC5→partner) and Y-score (partner→DNAJC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.398	+2.817	.002	.036	3	1
UCEC	Rab11 →	-0.191	-3.169	.016	.020	3	1
UCEC	Cyclin-B1 →	+0.784	+3.169	.010	.020	3	1
UCEC	C-Raf →	+0.208	+3.169	.008	.020	1	2
UCEC	ASNS →	+0.663	+3.169	<.001	.020	1	1
UCEC	Caspase-8 →	-0.348	-3.169	.011	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Ku80 by DNAJC5 expression — UCEC

Explore this box plot interactively →