DNAJC4

Across TCGA pan-cancer cohorts, DNAJC4 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated DNAJC4 data layer compared with 3 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher DNAJC4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DNAJC4 expression acts as an unfavorable survival marker, although some lineages such as UVM and MESO show a favorable association.

ACC, UVM, and MESO are the cancer types where DNAJC4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	II,III,IV	0.196	0.640	<.001	80	view →
UVM	DFS	Median	All	0.766	0.433	<.001	78	view →
MESO	OS	Median	All	0.399	0.190	<.001	50	view →
KIRP	DFS	Quartile	All	0.876	0.530	.004	44	view →
COAD	DFS	Median	IV	0.355	0.604	.003	42	view →
KICH	OS	Tertile	III,IV	0.200	1.000	.006	40	view →
OV	OS	Median	All	0.868	0.811	.003	36	view →
ESCA	OS	Median	All	0.562	0.385	.009	27	view →
LAML	DFS	Tertile	All	0.416	0.698	.021	22	view →
LGG	OS	Median	All	0.863	0.924	.003	14	view →
THCA	DFS	Tertile	IV	0.503	0.865	.008	7	view →
BRCA	OS	Median	All	0.942	0.905	.014	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

DNAJC4–ACC (DFS)

Open the ACC breakdown →