DNAJC3

Across TCGA patient cohorts, DNAJC3 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAJC3-associated genes across cancer lineages are A-Raf_pS299, EGFR_pY1068, and GATA6. Each is linked with DNAJC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAJC3-to-partner and partner-to-DNAJC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by DNAJC3-low versus DNAJC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJC3→partner) and Y-score (partner→DNAJC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.103	-3.321	.031	.010	3	2
UCEC	EGFR_pY1068 →	-0.292	-4.169	.003	<.001	3	1
UCEC	GATA6 →	-0.122	-1.899	.049	.016	3	1
UCEC	INPP4B →	-0.318	-2.401	.014	.003	3	1
UCEC	JNK_pT183_Y185 →	-0.208	-3.700	.002	.001	3	1
UCEC	Ku80 →	+0.221	+1.920	.020	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

A-Raf_pS299 by DNAJC3 expression — UCEC

Explore this box plot interactively →