DNAJC21

Across TCGA pan-cancer cohorts, DNAJC21 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DNAJC21 data layer compared with 23 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DNAJC21 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DNAJC21 expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

HNSC, LIHC, and BLCA are the cancer types where DNAJC21 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.205	0.686	.010	24	view →
LIHC	OS	Median	All	0.144	0.688	.013	9	view →
BLCA	DFS	Median	All	1.000	0.609	.043	2	view →
UCEC	DFS	Median	All	0.966	0.830	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DNAJC21–HNSC (OS)

Open the HNSC breakdown →