DNAJC21

Across TCGA patient cohorts, DNAJC21 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAJC21-associated genes across cancer lineages are ERK2, 4E-BP1, and EGFR_pY1068. Each is linked with DNAJC21 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAJC21-to-partner and partner-to-DNAJC21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by DNAJC21-low versus DNAJC21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJC21→partner) and Y-score (partner→DNAJC21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.190	+3.000	.005	<.001	3	2
UCEC	4E-BP1 →	+0.244	+3.169	.010	.018	3	2
UCEC	EGFR_pY1068 →	-0.187	-1.906	.034	.015	3	1
UCEC	EGFR →	-0.185	-3.295	.001	.009	3	1
UCEC	eIF4E →	+0.183	+2.472	.014	.010	3	1
UCEC	A-Raf_pS299 →	-0.131	-2.321	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

ERK2 by DNAJC21 expression — UCEC

Explore this box plot interactively →