DNAJC21

Across TCGA cell cohorts, DNAJC21 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DNAJC21-associated genes across cancer lineages are IQCF5 and IL20. Each is linked with DNAJC21 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAJC21-to-partner and partner-to-DNAJC21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF5 grouped by DNAJC21-low versus DNAJC21-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJC21→partner) and Y-score (partner→DNAJC21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	IQCF5 →	+0.056	+5.357	<.001	.003	3	1
LARGE_INTESTINE	IL20 →	+0.331	+3.662	<.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

IQCF5 by DNAJC21 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →