DNAJC17

Across TCGA patient cohorts, DNAJC17 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAJC17-associated genes across cancer lineages are MSH2, VHL, and Caspase-7-cleavedD198. Each is linked with DNAJC17 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAJC17-to-partner and partner-to-DNAJC17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by DNAJC17-low versus DNAJC17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJC17→partner) and Y-score (partner→DNAJC17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.314	-2.295	.003	.033	3	1
UCEC	VHL →	-0.826	-3.321	.008	.010	3	1
UCEC	Caspase-7-cleavedD198 →	+1.019	+3.321	<.001	.009	3	1
UCEC	ERK2 →	+0.226	+3.321	.011	.010	2	1
UCEC	p90 RSK →	+0.202	+3.179	.023	.010	2	1
UCEC	Annexin-1 →	+0.688	+3.019	.005	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MSH2 by DNAJC17 expression — UCEC

Explore this box plot interactively →