DNAJC13

Across TCGA pan-cancer cohorts, DNAJC13 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated DNAJC13 data layer compared with 10 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher DNAJC13 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DNAJC13 expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

UVM, KIRC, and UCS are the cancer types where DNAJC13 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	II,III,IV	0.328	0.882	<.001	103	view →
KIRC	OS	Tertile	All	0.747	0.558	<.001	85	view →
UCS	DFS	Median	IV	0.952	0.367	.001	66	view →
KICH	DFS	Tertile	All	0.573	0.970	<.001	60	view →
HNSC	DFS	Tertile	All	0.779	0.633	.002	50	view →
LUSC	OS	Median	III,IV	0.571	0.804	<.001	37	view →
LIHC	DFS	Tertile	All	0.247	0.561	<.001	35	view →
ACC	OS	Quartile	All	0.308	0.705	.001	33	view →
MESO	DFS	Tertile	III,IV	0.269	0.493	.012	31	view →
THCA	OS	Median	II,III,IV	0.839	0.979	.007	23	view →
PAAD	OS	Quartile	All	0.227	0.579	.001	22	view →
UCEC	DFS	Quartile	All	0.633	0.840	.005	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

DNAJC13–UVM (DFS)

Open the UVM breakdown →