DNAJC12

Across TCGA patient cohorts, DNAJC12 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAJC12-associated genes across cancer lineages are Ku80, S6_pS240_S244, and SF2. Each is linked with DNAJC12 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAJC12-to-partner and partner-to-DNAJC12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by DNAJC12-low versus DNAJC12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJC12→partner) and Y-score (partner→DNAJC12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.326	+3.013	.016	.019	3	1
UCEC	S6_pS240_S244 →	+0.593	+3.000	.011	.037	3	1
UCEC	SF2 →	-0.167	-2.986	.008	.037	3	1
UCEC	STAT3_pY705 →	-0.422	-3.000	.005	.037	3	1
UCEC	Tuberin_pT1462 →	+0.317	+2.817	.017	.036	3	1
UCEC	Tuberin →	+0.472	+3.000	.002	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Ku80 by DNAJC12 expression — UCEC

Explore this box plot interactively →