DNAJC10

Across TCGA patient cohorts, DNAJC10 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAJC10-associated genes across cancer lineages are 4E-BP1, PCNA, and TIGAR. Each is linked with DNAJC10 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAJC10-to-partner and partner-to-DNAJC10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by DNAJC10-low versus DNAJC10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJC10→partner) and Y-score (partner→DNAJC10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.248	+2.321	.012	.033	3	2
UCEC	PCNA →	+0.207	+1.906	.009	.015	3	2
UCEC	TIGAR →	+0.110	+1.874	.049	.004	3	2
UCEC	Caspase-7-cleavedD198 →	+0.595	+2.000	.006	.029	3	2
UCEC	Cyclin-B1 →	+0.526	+1.502	.010	.030	3	2
UCEC	EGFR_pY1068 →	-0.293	-2.247	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

4E-BP1 by DNAJC10 expression — UCEC

Explore this box plot interactively →