DNAJC1

Across TCGA pan-cancer cohorts, DNAJC1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DNAJC1 data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher DNAJC1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DNAJC1 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

LSCC, HNSC, and LUAD are the cancer types where DNAJC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.655	0.881	.003	10	view →
HNSC	DFS	Tertile	III,IV	0.911	1.000	.036	3	view →
LUAD	OS	Median	II,III,IV	0.899	0.963	.046	1	view →
GBM	OS	Median	All	0.907	0.642	.022	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DNAJC1–LSCC (DFS)

Open the LSCC breakdown →