DNAJC1

Across TCGA cell cohorts, DNAJC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,191 significant associations in total. BONE shows the largest number of these associations.

The most reproducible DNAJC1-associated GO terms across cancer lineages are Regulation of response to endoplasmic reticulum stress, Sphingolipid metabolic process, and Positive regulation of protein exit from endoplasmic reticulum. Each is linked with DNAJC1 in more than 9 cancer types. Because this analysis shows association rather than direction, both DNAJC1-to-partner and partner-to-DNAJC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of response to endoplasmic reticulum stress grouped by DNAJC1-low versus DNAJC1-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJC1→partner) and Y-score (partner→DNAJC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of response to endoplasmic reticulum stress →	+0.057	+1.096	<.001	.001	3	10
BONE	Sphingolipid metabolic process →	+0.079	+1.328	<.001	<.001	3	10
KIDNEY	Positive regulation of protein exit from endoplasmic reticulum →	+0.132	+1.001	<.001	<.001	3	10
BONE	Cellular response to unfolded protein →	+0.086	+1.296	<.001	<.001	3	9
BONE	Cellular response to topologically incorrect protein →	+0.074	+1.239	.002	<.001	3	9
BONE	Negative regulation of proteolysis →	+0.186	+1.238	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,191 associations by consensus.

Regulation of response to endoplasmic reticulum stress by DNAJC1 expression — SOFT_TISSUE

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