DNAJB9

Across TCGA patient cohorts, DNAJB9 mutation is significantly associated with the RNA expression of many other genes, with 80 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAJB9-associated genes across cancer lineages are USP9YP2, CHD3, and NINJ2. Each is linked with DNAJB9 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAJB9-to-partner and partner-to-DNAJB9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP9YP2 grouped by DNAJB9-low versus DNAJB9-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJB9→partner) and Y-score (partner→DNAJB9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	USP9YP2 →	+0.039	+7.731	<.001	.009	3	2
UCEC	CHD3 →	+0.669	+3.480	.001	.002	3	1
UCEC	NINJ2 →	+0.964	+3.343	.001	.005	3	1
UCEC	CTU2 →	+0.575	+3.235	<.001	.008	3	1
UCEC	SNX11 →	+0.408	+3.257	.005	.008	3	1
UCEC	SIRT6 →	+0.509	+3.470	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 80 associations by consensus.

USP9YP2 by DNAJB9 expression — BRCA

Explore this box plot interactively →