DNAJB8

Across TCGA pan-cancer cohorts, DNAJB8 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DNAJB8 data layer compared with 12 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DNAJB8 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DNAJB8 expression acts as an unfavorable survival marker, although some lineages such as STAD show a favorable association.

HNSC, LIHC, and STAD are the cancer types where DNAJB8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.029	0.675	<.001	18	view →
LIHC	OS	Median	All	0.255	0.773	.012	9	view →
STAD	DFS	Median	All	1.000	0.383	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

DNAJB8–HNSC (OS)

Open the HNSC breakdown →