DNAJB7

Across TCGA pan-cancer cohorts, DNAJB7 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of DNAJB7’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where DNAJB7 RNA is repressed in tumor relative to normal tissue. In most cancer types DNAJB7 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

THCA, COAD, and LIHC are the cancer types where DNAJB7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DNAJB7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.150	<.001	6	view →
COAD	Female	All	−0.093	.007	5	view →
LIHC	All	All	+0.028	.009	5	view →
LUSC	All	All	+0.138	.005	4	view →
BRCA	All	III,IV	−0.083	.028	2	view →
STAD	Male	IV	+0.130	.028	1	view →
HNSC	Male	II,III,IV	+0.041	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

DNAJB7–THCA

Open the THCA breakdown →