Across TCGA pan-cancer cohorts, DNAJB6P4 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of DNAJB6P4’s most consistent transcriptional readouts.
The strongest signal is observed in bladder urothelial carcinoma (BLCA), where DNAJB6P4 RNA is repressed in tumor relative to normal tissue. In most cancer types DNAJB6P4 is over-expressed in tumor, although a few such as BLCA and THCA show the opposite, repressed pattern.
BLCA and THCA are the cancer types where DNAJB6P4 tumor–normal differential expression is most reproducible.