DNAJB6

Across TCGA pan-cancer cohorts, DNAJB6 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DNAJB6 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DNAJB6 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DNAJB6 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

CCRCC, UCEC, and HNSC are the cancer types where DNAJB6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.749	0.921	.002	38	view →
UCEC	OS	Median	III,IV	0.433	1.000	.007	12	view →
HNSC	DFS	Tertile	II,III,IV	1.000	0.886	.004	10	view →
LSCC	DFS	Tertile	All	0.971	0.920	.035	4	view →
LUAD	DFS	Quartile	III,IV	0.633	0.248	.021	3	view →
PDAC	DFS	Median	II,III,IV	0.506	0.311	.014	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DNAJB6–CCRCC (OS)

Open the CCRCC breakdown →