DNAJB6

Across TCGA cell cohorts, DNAJB6 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DNAJB6-associated genes across cancer lineages are C6orf118, DEFA4, and OR6Q1. Each is linked with DNAJB6 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAJB6-to-partner and partner-to-DNAJB6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C6orf118 grouped by DNAJB6-low versus DNAJB6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJB6→partner) and Y-score (partner→DNAJB6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C6orf118 →	+0.192	+3.793	<.001	.007	3	1
LARGE_INTESTINE	DEFA4 →	+0.032	+4.437	<.001	.004	3	1
LARGE_INTESTINE	OR6Q1 →	+0.018	+4.437	<.001	.004	3	1
BLOOD_Lymphoma	SLC7A13 →	+0.006	+6.247	<.001	<.001	3	1
BLOOD_Lymphoma	OR4D6 →	+0.018	+5.209	.002	.005	3	1
BLOOD_Lymphoma	OR51T1 →	+0.029	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

C6orf118 by DNAJB6 expression — LARGE_INTESTINE

Explore this box plot interactively →