DNAJB4

Across TCGA patient cohorts, DNAJB4 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAJB4-associated genes across cancer lineages are 14-3-3_beta, EGFR, and eIF4G. Each is linked with DNAJB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAJB4-to-partner and partner-to-DNAJB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by DNAJB4-low versus DNAJB4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJB4→partner) and Y-score (partner→DNAJB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.090	-1.401	.016	.046	3	1
UCEC	EGFR →	-0.180	-3.143	.002	.018	3	1
UCEC	eIF4G →	+0.231	+1.415	.047	.046	3	1
UCEC	A-Raf_pS299 →	-0.130	-3.584	.003	.002	3	1
UCEC	FASN →	+0.323	+1.700	.029	.042	3	1
UCEC	FoxM1 →	+0.277	+2.169	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

14-3-3_beta by DNAJB4 expression — UCEC

Explore this box plot interactively →