DNAJB4

Across TCGA cell cohorts, DNAJB4 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DNAJB4-associated genes across cancer lineages are SPRR1A, OR10A3, and TEX43. Each is linked with DNAJB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAJB4-to-partner and partner-to-DNAJB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPRR1A grouped by DNAJB4-low versus DNAJB4-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJB4→partner) and Y-score (partner→DNAJB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SPRR1A →	+0.386	+4.930	<.001	.008	3	1
BLOOD_Leukemia	OR10A3 →	+0.041	+5.539	<.001	.003	3	1
BLOOD_Lymphoma	TEX43 →	+0.065	+4.643	<.001	.005	3	1
SKIN	OR5A1 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	C8A →	+0.019	+3.421	<.001	<.001	3	1
LARGE_INTESTINE	ARX →	+0.674	+3.302	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

SPRR1A by DNAJB4 expression — SOFT_TISSUE

Explore this box plot interactively →