Across TCGA pan-cancer cohorts, DNAJB3 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of DNAJB3’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where DNAJB3 RNA is repressed in tumor relative to normal tissue. In most cancer types DNAJB3 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.
KICH, LUSC, and KIRC are the cancer types where DNAJB3 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DNAJB3 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.