DNAJB2

Across TCGA cell cohorts, DNAJB2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,355 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DNAJB2-associated GO terms across cancer lineages are Negative regulation of protein deubiquitination, Endosomal transport, and Regulation of macroautophagy. Each is linked with DNAJB2 in more than 19 cancer types. Because this analysis shows association rather than direction, both DNAJB2-to-partner and partner-to-DNAJB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of protein deubiquitination grouped by DNAJB2-low versus DNAJB2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJB2→partner) and Y-score (partner→DNAJB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of protein deubiquitination →	+0.246	+1.307	<.001	<.001	3	20
BONE	Endosomal transport →	+0.064	+1.439	.009	<.001	3	19
STOMACH	Regulation of macroautophagy →	+0.084	+1.430	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Process utilizing autophagic mechanism →	+0.067	+1.221	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Autophagy →	+0.067	+1.221	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Vacuole organization →	+0.056	+0.944	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,355 associations by consensus.

Negative regulation of protein deubiquitination by DNAJB2 expression — LUNG_SCLC

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