DNAJB14

Across TCGA pan-cancer cohorts, DNAJB14 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated DNAJB14 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DNAJB14 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated DNAJB14 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, LUAD, and LSCC are the cancer types where DNAJB14 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	II,III,IV	0.887	0.603	.002	32	view →
LUAD	DFS	Median	II,III,IV	0.220	0.790	.005	29	view →
LSCC	OS	Tertile	III,IV	0.363	0.871	.002	15	view →
OV	DFS	Tertile	All	0.535	0.922	.025	8	view →
CCRCC	OS	Median	II,III,IV	0.857	0.588	.016	3	view →
GBM	OS	Quartile	All	0.423	0.772	.021	3	view →
PDAC	DFS	Median	III,IV	0.510	0.202	.016	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

DNAJB14–HNSC (OS)

Open the HNSC breakdown →