DNAJB14

Across TCGA patient cohorts, DNAJB14 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAJB14-associated genes across cancer lineages are ACC_pS79, MEK1, and p62 Lck ligand. Each is linked with DNAJB14 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAJB14-to-partner and partner-to-DNAJB14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC_pS79 grouped by DNAJB14-low versus DNAJB14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJB14→partner) and Y-score (partner→DNAJB14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC_pS79 →	+0.305	+1.884	.022	.030	3	1
UCEC	MEK1 →	+0.491	+2.584	<.001	.001	3	1
UCEC	p62 Lck ligand →	+0.435	+3.459	<.001	.005	3	1
UCEC	PCNA →	+0.213	+3.321	.010	.009	3	1
UCEC	Rab11 →	-0.130	-1.678	.019	.023	3	1
UCEC	VHL →	-0.539	-1.700	.038	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

ACC_pS79 by DNAJB14 expression — UCEC

Explore this box plot interactively →