DNAJB12

Across TCGA pan-cancer cohorts, DNAJB12 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DNAJB12 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DNAJB12 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DNAJB12 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, LUAD, and CCRCC are the cancer types where DNAJB12 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	IV	0.915	0.551	<.001	19	view →
LUAD	DFS	Quartile	II,III,IV	0.154	0.748	.003	15	view →
CCRCC	OS	Median	All	0.656	1.000	.006	15	view →
PDAC	OS	Tertile	III,IV	0.694	0.288	.035	2	view →
LSCC	OS	Median	All	0.813	1.000	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DNAJB12–HNSC (DFS)

Open the HNSC breakdown →