DNAJB12

Across TCGA patient cohorts, DNAJB12 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAJB12-associated genes across cancer lineages are Rad50, FOXO3a_pS318_S321, and JNK2. Each is linked with DNAJB12 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAJB12-to-partner and partner-to-DNAJB12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by DNAJB12-low versus DNAJB12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJB12→partner) and Y-score (partner→DNAJB12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.217	-1.700	.034	.044	3	2
UCEC	FOXO3a_pS318_S321 →	-0.129	-2.321	.014	.033	3	1
UCEC	JNK2 →	+0.306	+2.594	<.001	.006	3	1
UCEC	Ku80 →	+0.287	+1.713	.004	.027	3	1
UCEC	MEK1 →	+0.421	+2.584	.006	.010	3	1
UCEC	mTOR_pS2448 →	-0.163	-2.222	.010	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Rad50 by DNAJB12 expression — UCEC

Explore this box plot interactively →