DNAJB11

Across TCGA patient cohorts, DNAJB11 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAJB11-associated genes across cancer lineages are ATM, 14-3-3_beta, and FOXO3a_pS318_S321. Each is linked with DNAJB11 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAJB11-to-partner and partner-to-DNAJB11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by DNAJB11-low versus DNAJB11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJB11→partner) and Y-score (partner→DNAJB11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.445	-2.000	.012	.010	3	2
UCEC	14-3-3_beta →	-0.087	-1.973	.026	.029	3	1
UCEC	FOXO3a_pS318_S321 →	-0.109	-1.700	.026	.040	3	1
UCEC	ACVRL1 →	-0.117	-2.308	.028	.033	3	1
UCEC	JNK_pT183_Y185 →	-0.167	-2.321	.011	.033	3	1
UCEC	Ku80 →	+0.286	+2.013	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

ATM by DNAJB11 expression — UCEC

Explore this box plot interactively →