DNAJB11

Across TCGA cell cohorts, DNAJB11 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DNAJB11-associated genes across cancer lineages are DEFB132, IFNA10, and GJE1. Each is linked with DNAJB11 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAJB11-to-partner and partner-to-DNAJB11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB132 grouped by DNAJB11-low versus DNAJB11-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJB11→partner) and Y-score (partner→DNAJB11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DEFB132 →	+0.012	+5.029	<.001	.006	3	1
LUNG_SCLC	IFNA10 →	+0.154	+5.029	<.001	.006	3	1
LUNG_SCLC	GJE1 →	+0.026	+5.643	<.001	.002	3	1
LARGE_INTESTINE	MAGEB4 →	+0.029	+5.415	<.001	.004	3	1
LARGE_INTESTINE	STRA8 →	+0.215	+5.415	<.001	.004	3	1
LARGE_INTESTINE	ZNF804B →	+0.022	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

DEFB132 by DNAJB11 expression — LUNG_SCLC

Explore this box plot interactively →