DNAJB1

Across TCGA cell cohorts, DNAJB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,164 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DNAJB1-associated GO terms across cancer lineages are Positive regulation of protein folding, Regulation of glycolytic process through fructose-6-phosphate, and Negative regulation of glycolytic process through fructose-6-phosphate. Each is linked with DNAJB1 in more than 11 cancer types. Because this analysis shows association rather than direction, both DNAJB1-to-partner and partner-to-DNAJB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of protein folding grouped by DNAJB1-low versus DNAJB1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJB1→partner) and Y-score (partner→DNAJB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of protein folding →	+0.202	+0.798	<.001	<.001	3	12
LIVER	Regulation of glycolytic process through fructose-6-phosphate →	+0.143	+0.857	.005	.004	3	11
LIVER	Negative regulation of glycolytic process through fructose-6-phosphate →	+0.143	+0.857	.005	.004	3	11
KIDNEY	Negative regulation of protein localization to chromatin →	+0.078	+0.524	.002	.001	3	8
BONE	L-amino acid metabolic process →	-0.091	-0.560	<.001	.002	3	8
BLOOD_Leukemia	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.090	+0.590	<.001	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,164 associations by consensus.

Positive regulation of protein folding by DNAJB1 expression — BONE

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